Targeted drug delivery using magnetic nanoparticles: A Review

Rahul Lalge, Sneha Rathi

Abstract


Continuing improvement in the pharmacological and therapeutic properties of drugs is the driving force of the revolution in novel drug delivery systems. Amongst the plethora of avenues explored for the new ways of targeted drug delivery, magnetic nanoparticles (MNPs) grabbed foremost attention offering local drug delivery, reduced toxic reactions and controlled drug release for prolonged period of time addressing problems of healthy tissue damage and drug wastage. Due to their unique purposes, magnetic nano-particles have been of great interest. An attempt is made herein to review the concept of MNPs, their advantages, methods of preparation, characterization, applications in drug delivery. Usage of MNPs depends largely on the preparation process to select optimal conditions and election of agents to modify their surface. This review deals with use of MNPs in Tumor hypoxia or tumors in low oxygen concentration as well as magnetic drug targeting using core–shell magnetic carrier nano-particles (Iron and Gold nano-particles) loaded with anti-cancer drugs. This review deals with the disadvantages of MNPs and how they can be overcome. It focuses on exemplifying different drug formulations formulated into MNPs. Future prospective, challenges in drug delivery and scope of MNPs are briefly discussed.

Keywords


Magnetic nanoparticles (MNPs), controlled drug release, drug wastage, Tumor hypoxia, core–shell, Magnetic drug targeting, Super-paramagnetic iron oxide nanoparticles (SPIONs)

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References


Jana Chomouckaa, Jana Drbohlavovaa, Dalibor Huskab, Vojtech Adamb, Rene Kizekb, Jaromir Hubaleka, Magnetic nanoparticles and targeted drug delivering, Pharmalogical Research, Vol. 62 (2010), 144-149.

Vicky V. Mody, Arthur Cox, Samit Shah, Ajay Singh, Wesley Bevins, Harish Parihar, Magnetic nanoparticle drug delivery systems for targeting tumor, Applied Nanoscience (2013), 204-216.

Sibnath Kayal and Raju Vijayaraghavan Ramanujan, Anti-Cancer Drug Loaded Iron–Gold Core–Shell Nanoparticles (Fe@Au) for Magnetic Drug Targeting, Journal of Nanoscience and Nanotechnology, Vol. 10 (2010), 1–13.

T.K. Indira and P.K. Lakshmi, Magnetic Nanoparticles – A Review, International Journal of Pharmaceutical Sciences and Nanotechnolgy, Vol. 3, Issue 3 (2010), 1035-1042.

Michael J. Sailor and Ji-Ho Park, Hybrid Nanoparticles for Detection and Treatment of Cancer, Advanced Materials, 24 (2012), 3779–3802.

Avnesh S. Thakor, Sanjiv S. Gambhir, Nanooncology: The Future of Cancer Diagnosis and Therapy, CA: A Cancer Journal for Clinicians, Vol. 63, Issue 6 (2013), 395-418.

Omid Veiseh, Jonathan Gunn, and Miqin Zhang, Design & fabrication of magnetic nanoparticles for targeted drug delivery & imaging, Advanced Drug Delivery Review, Vol. 62, Issue 3 (2010), 284-304.

M. Mahmoudi, S. Sant, T. Sen, B. Wang, S. Laurent, Superparamagnetic iron oxide nanoparticles: development, surface modification and applications in chemotherapy, Advanced Drug Delivery Reviews, Vol. 63, No. 1-2 (2011), 24-46.

Pedro Tartaj, María del Puerto Morales, Sabino Veintemillas-Verdaguer, Teresita González-Carreño and Carlos J Serna, The preparation of magnetic nanoparticles for applications in biomedicine, Journal of Applied Physics D: Applied Physics, Vol. 36, No. 13 (2003), R182.

G.M. Barratt, Therapeutic applications of colloidal drug carriers, Pharmaceutical Science and Technology Today, Vol. 3 (2000), 163–171.

Reto Strobel, Sotiris E., Direct synthesis of maghemite, magnetite and wustite nanoparticles by flame spray pyrolysis, Advanced Powder Technology, Vol. 20, Issue 2 (2009), 190-194.

S. J. Cho, B. R. Jarrett, A. Y. Louie, and S. M. Kauzlarich, Gold-coated iron nanoparticles: a novel magnetic resonance agent for T1 and T2 weighted imaging, Nanotechnology, Vol. 17, No. 3 (2006), 640.

A. K. Gupta, M. Gupta, Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications, Biomaterials, Vol. 26, Issue 18 (2005), 3995-4021.

C. E. Devita, Physician’s Cancer Chemotherapy Drug Manual, Jones and Barlett, Sudbury (2007).

J. Lin, W. Zhou, A. Kumbhar, J. Wiemann, J. Fang, E. E. Carpenter, C. J. O’Connor, Gold-coated iron (Fe@Au) nanoparticles: synthesis, characterization, and magnetic field-induced self-assembly, Journal of Solid State Chemistry, Vol. 159, Issue 1 (2001), 26-31.

Ally J., Martin B., Behrad Khamesee M., Roa W., Amirfazli A., Magnetic targeting of aerosol particles for cancer therapy, Journal of Magnetism and Magnetic Material, Vol. 293 (2005), 442-449.

Balkwill D.L., Maratea D., Blakemore R.P., Ultrastructure of a magnetotactic spirillum, Journal of Bacteriology, Vol. 141 (1980), 1399-1408.

Chertok B., David A.E., Yang V.C., Polyethyleneimine-modified iron oxide nanoparticles for brain tumor drug delivery using magnetic targeting and intra-carotid administration, Biomaterials, Vol. 31 (2010), 6317–6324.

Hafeli U., Schutt W., Teller J., Zborowski M., Scientific and clinical applications of magnetic carriers, Plenum Publishing Corp, NY, USA (1997).

Huth S., Lausier J., Gersting S. W., Rudolph C., Plank C., Welsch U., Rosenecker J., Insights into the mechanism of magnetofection using PEI-based magnetofectins for gene transfer, The Journal of Gene Medicine, Vol. 6, Issue 8 (2004), 923-936.

Kreuter J., Nanoparticulate systems for brain delivery of drugs, Advanced Drug Delivery Reviews, Vol. 47, Issue 1 (2001), 65-81.

Krishnan K. M., Biomedical nanomagnetics: a spin through possibilities in imaging diagnostics, and therapy. IEEE Transaction on Magnetics, Vol. 46, Issue 7 (2010), 2523-2558.

Liu F., Laurent S., Fattahi H., Elst L. V., Muller R. N., Superparamagnetic nanosystems based on iron oxide nanoparticles for biomedical imaging, Nanomedicine, Vol. 6, No. 3 (2011), 519-528.

Mody V., Singh A., Bevins W., Basics of magnetic nanoparticles for their application in the field of magnetic fluid hyperthermia, European Journal of Nanomedicine, Vol. 5, Issue 1 (2013), 11-21.

Paliwal S. R., Paliwal R., Mishra N., Mehta A., Vyas S. P., A novel cancer targeting approach based on estrone anchored stealth liposome for site-specific breast cancer therapy. Current Cancer Drug Targets, Vol. 10, Issue 3 (2010), 343-353.

Widder K. J., Senyel A. E., Scarpelli G. D., Magnetic microspheres: a model system of site specific drug delivery in vivo, Proc Soc Exp Biol Med, Vol. 158, Issue 2 (1978), 141-146.

Reddy L. H., Arias J. L., Nicolas J., Couvreur P., Magnetic

nanoparticles: design and characterization, toxicity and biocompatibility, pharmaceutical and biomedical applications, Chemical Reviews, Vol. 112, Issue 11 (2012), 5818-5878.

Sun C., Lee J. S. H., Zhang M., Magnetic nanoparticles in MR imaging and drug delivery, Advanced Drug Delivery Reviews, Vol. 60, Issue 11 (2008), 1252-1265.

Omid Veiseh, Jonathan Gunn, and Miqin Zhang, Design and fabrication of magnetic nanoparticles for targeted drug delivery and imaging, Advanced Drug Delivery Review, Vol. 62, Issue 3 (2010), 284-

http://umm.edu/health/medical/reports/articles/nonsmall-cell-lung-cancer

http://www.aihw.gov.au/chronic-respiratory-conditions/

Michał Piotr Marszałl, Application of Magnetic Nanoparticles in Pharmaceutical Sciences, Pharmaceutical Research, Vol. 28, Issue 3 (2011), 480-483.

The Development of Magnetic Drug Delivery and Disposition Michał Piotr Marszałł, www.intechopen.com

Colin J. Stirrat, David E. Newby, Jennifer M.J. Robson, Maurits A. Jansen, The Use of Superparamagnetic Iron Oxide nanoparticles to assess cardiac inflammation., Current Cardiovascular Imaging, (2014), 7:9263.

H. Markides, M. Rotherham, and A. J. El Haj, Biocompatibility and Toxicity of Magnetic Nanoparticles in Regenerative Medicine, Journal of Nanomaterials, Volume 2012 (2012), and Article ID 614094.

Christina Janko, Stephan Dürr, Luis E. Munoz, Stefan Lyer, Ricardo Chaurio, Rainer Tietze, Sarah von Löhneysen, Christine Schorn, Martin Herrmann, Christoph Alexiou, Magnetic Drug Targeting Reduces the Chemotherapeutic Burden on Circulating Leukocytes, International Journal of Molecular Sciences, Vol. 14, Issue 4 (2013), 7341-7355.


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